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. Author manuscript; available in PMC: 2012 Mar 22.
Published in final edited form as: Biochemistry. 2011 Jan 26;50(11):1808–1817. doi: 10.1021/bi101859k

Figure 8.

Figure 8

The binding of CAPS to APAH mimics the binding of the tetrahedral intermediate. (A) Simulated annealing omit map of CAPS contoured at 4 σ. Metal coordination, hydrogen bond, and cation-π interactions are shown as black, orange, and green dashed lines, respectively. Atoms are color-coded as follows: C = yellow (APAH) or gray (CAPS); N = blue; O = red; S = orange; Zn2+ = magenta sphere. (B) The sulfonate group of CAPS mimics the tetrahedral intermediate that forms during APAH hydrolysis reaction (C).