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Relative activities of APAH and HDAC8 with various substrates
| AcPuta | L-Lys(ε-acetyl)-coumarin | Acetylated Tetrapeptideb | |
|---|---|---|---|
| APAH | 1.000 | 450 ± 20 | 0.06 ± 0.02 |
| HDAC8 | < 0.002c | 1.000 | 1.000 |
Deacetylase activity measured using the standard polyamine deacetylase assay with acetylputrescine.
Deacetylase activity measured using the HDAC8 substrate N-acetyl-L-Arg-L-His-L-Lys(ε-acetyl)-L-Lys(ε-acetyl)-coumarin.
Lower limit of detection. All measurements were made in triplicate.
