Figure 5.

Basolateral amygdala (BLA) D3-like receptors (D3Rs) differentially modulate γ-aminobutyric acid (GABA)ergic release at BLA local and lateral paracapsular cell (LPC) GABAergic synapses. Paired electrical stimuli were delivered to either local (left, a) or LPC (right, c) GABAergic synapses using either 50- or 250-ms (not shown) inter-stimulus intervals. In the insets, the amplitude of the first synaptic response in the presence of PD128907 has been normalized to the baseline inhibitory postsynaptic current (IPSC) amplitude to illustrate the relative effects of the D3 receptor agonist on the two synaptic responses. At the 50-ms stimulus interval, the ratio of the IPSC amplitude generated from the second stimulus relative to the first stimulus was significantly altered by PD128907 at local synapses (b; n=7, ^*P<0.05, t-test), but not at LPC synapses (d; n=6, P>0.05). The IPSC amplitude ratios were not altered by PD128907 at the 250-ms stimulus interval at either synapse.