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. 2010 Oct 22;2(1):63–67. doi: 10.1021/ml1002162

Table 2. Anti-RT and Anti-HIV Activities of Inhibitors 11−18.

    HIV-1
compd RT IC50a (μM) EC50b (μM) CC50c (μM) TId
11 6.2 0.0080 >20 >2500
12 >100 >10    
13 0.17 0.024 >20 >830
14 >100 >10    
15 9.4 1.1 >20 >18
16 1.5 >10    
17 13 4.3 >20 >4.7
18 >100 >10    
3 0.040 0.013 >20 >1500
a

Concentration inhibiting enzyme activity by 50%.

b

Concentration inhibiting virus replication by 50%.

c

Concentration resulting in 50% cell death.

d

Therapeutic index, defined by CC50/EC50.