Table 1.
ADME properties for selected PYT compounds
Potency (EC50) | Solubility (16h) | Human Metabolic Potential (T1/2) | Mouse Metabolic Potential (T1/2) | Plasma Stability (Calc T1/2) | |
---|---|---|---|---|---|
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1.68 uM | 62.5 uM | 61 min | 39 min | 60.5 min |
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0.68 uM | 105 uM | 15 min | 11 min | 21.8 min |
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3.23 uM | 31.3 uM | 31 min | 22 min | 131.2 min |