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. Author manuscript; available in PMC: 2012 Apr 14.
Published in final edited form as: J Med Chem. 2011 Mar 4;54(7):2409–2421. doi: 10.1021/jm101549k

Table 1.

ADME properties for selected PYT compounds

Potency (EC50) Solubility (16h) Human Metabolic Potential (T1/2) Mouse Metabolic Potential (T1/2) Plasma Stability (Calc T1/2)
graphic file with name nihms278864t1.jpg 1.68 uM 62.5 uM 61 min 39 min 60.5 min
graphic file with name nihms278864t2.jpg 0.68 uM 105 uM 15 min 11 min 21.8 min
graphic file with name nihms278864t3.jpg 3.23 uM 31.3 uM 31 min 22 min 131.2 min
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