Table 2. U1-70K T-cell epitopes.
Sequence | Species | Disease, assay | Reference |
---|---|---|---|
57–77 | Mouse | MRL/lpr, proliferation following immunization with U1-70K 131–151 | (76) |
92–202 | Human | CTD, T-cell clones | (82) |
131–151 | Mouse/human | MRL/lpr, NZB × NZW, proliferation/SLE patients, proliferation | (67, 77, 146) |
131–151 (P140)* | Mouse/human | MRL/lpr, proliferation/SLE patients, proliferation | (144, 146) |
219–238 | Mouse | MRL/lpr, proliferation following immunization with U1-70K 131–151 | (76) |
336–437 | Human | SLE/MCTD, proliferation | (75) |
131–151 (P140) is a phosphorylation modification to serine residue 140 on U1-70K.
SLE, systemic lupus erythematosus; MCTD, mixed connective tissue disease.