Table 2. pD2 values for cumulative concentration response (relaxation) curve to vinpocetine, sildenafil, 8-Bromo-cGMP and Bay-41-2272.
Concentration-response curves to vinpocetine, sildenafil, 8-Bromo cGMP and Bay-41-2272 were performed in aortas contracted with PE (1µM) or small-mesenteric arteries contracted with U-46619 (1µM), from Ang II hypertensive and control rats.
| Aorta | Small-mesenteric artery | |||
|---|---|---|---|---|
| Incubation | Control | Ang II | Control | Ang II |
| Vinpocetine | 4.8±0.1 | 4.6±0.2 | 5.3±0.1 | 6.1±0.3* |
| Sildenafil | 4.3±0.3 | 3.8±0.6 | 5.2±0.2 | 4.75±0.6 |
| 8-Bromo cGMP | 4.6±0.2 | 4.6±0.2 | 4.5±0.2 | 4.6±0.2 |
| Bay-41-2272 | 5.3±008 | 5.4±0.09 | 6.8±0.06 | 6.94±0.11 |
Data are mean ± SEM (n=6).
*
p<0.05 vs. respective control group.
†
p<0.05 vs. respective vehicle group