TABLE 2.
Unadjusted Odds Ratio for Achieving the Minimum Projected Accrual by Study Closure Stratified by the Time-to-first Enrollment (with Adjusted Values)
| Time to First Patient Enrollment (months) | n | Number of Studies Achieving Minimum Accrual Goal at Closure (%) | Unadjusted Odds | P Value | Adjusted Odds* | P Value |
|---|---|---|---|---|---|---|
| [1–2) (referent) | 385 | 272 (70.6) | REFERENT | REFERENT | REFERENT | REFERENT |
| [2–6) | 304 | 184 (60.5) | 0.637 (0.464–0.875) | 0.005 | 0.616 (0.447–0.851) | 0.003 |
| [6–12) | 57 | 19 (33.3) | 0.208 (0.115–0.376) | ≤0.001 | 0.209 (0.115–0.380) | ≤0.001 |
| [12, ) | 18 | 5 (27.8) | 0.160 (0.056–0.459) | 0.001 | 0.183 (0.063–0.531) | 0.002 |
 | ||||||
*
Adjusted for Study Size, Phase, Cancer Incidence, and Cancer Mortality