TABLE 4.
Unadjusted Odds Ratio for Achieving the Minimum Projected Accruals by Study Closure Stratified Accrual Performance at the Expected Period (with Adjusted Values)
| Percent of minimum projected accrual achieved at Expected Time of Achievement** | n | Number of Studies Achieving Minimum Accrual Goal at Closure (%) | Unadjusted Odds | P Value | Adjusted Odds* | P Value |
|---|---|---|---|---|---|---|
| 0–19% | 97 | 42 (43.3%) | 0.065 (0.019–0.227) | P < 0.001 | 0.060 (0.017–0.213) | p≤0.001 |
| 20–39% | 159 | 93 (58.5%) | 0.121 (0.036–0.409) | p = 0.001 | 0.103 (0.030–0.335) | p≤0.001 |
| 40–59% | 135 | 93 (68.9%) | 0.190 (0.055–0.652) | p = 0.008 | 0.169 (0.049–0.586) | p = 0.005 |
| 60–79% | 89 | 76 (85.4%) | 0.501 (0.134–1.871) | p = 0.304 | 0.476 (0.127–1.792) | p = 0.273 |
| 80–99% (referent) | 38 | 35 (92.1%) | REFERENT | REFERENT | REFERENT | REFERENT |
| ≥ 100% | 85 | 85 (100%) | N/A | N/A | N/A | N/A |
 | ||||||
*
Adjusted for Study Size, Phase, Cancer Incidence, and Cancer Mortality
**
Trials closed prior to the expected time to achieve minimum accrual (n=151, 21.1%) were excluded