Table 2.
Preferred PTP1B Substrates Selected from Libraries IV (AX5pYX5NN) and library V (AX5pYX5EE)a
| Library IV (150 mM NaCl) | |
|---|---|
| Class I | NRSRMpYQRGLF |
| GTDHApYHDNLL | NHQQApYRVRRI |
| ADVFQpYKRNRW | PARXXpYSRIRR |
| IINSMpYRRGHH | QRGQNpYRRAVR |
| FTQNTpYTRRKH | RSNLRpYSRRIM |
| IISNQpYRFARR | RRRMTpYGSFGT |
| RRFSKpYRVDGR | |
| Class II | RRNXXpYFLKRA |
| RRRXXpYNTKMM | RKIGLpYRHLRM |
| ANRRFpYHRRRR | RKFGNpYRRHVS |
| AIAGIpYNRRKA | RHAGFpYINRRS |
| DGNXXpYRGTRR | RVGLGpYQKFAR |
| FQRFFpYRQSQR | STNGRpYFEIAQ |
| FKNRIpYGARRA | TAKNRpYSRNRR |
| GFAGGpYRRRHG | TRQQGpYRVKRR |
| HFPASpYTIRRK | VRRAFpYRTIGH |
| INRNIpYSRRXX | VNASRpYRRHKL |
| IERRLpYKRRVH | XXRNVpYRRRGF |
| IGHXXpYGRRKK | XXKGLpYSRAVR |
| MPRSApYMRRIK | XNSAFpYTRQKW |
| NSSRSpYIQRKR | |
| Library IV (500 mM NaCl) | |
| Class I | SSVIDpYFRKNT |
| WNGMDpYDNFVG | NGFDSpYNRFTR |
| IQSNDpYGIIHG | PTLGDpYPRVAQ |
| MEIEFpYGDAIP | EMQSMpYNRSFG |
| AEWDPpYGLDFI | |
| ESLELpYTEMSE | Class II |
| STWDMpYFGTAP | EENHIpYRRSRQ |
| HSSDTpYNEDSM | KERQTpYVRHHS |
| QDDWIpYFDTFQ | LRDKLpYMQRKR |
| FFEXXpYEVGWG | XESKPpYDFKRR |
| FEVWApYQSDXX | DSREGpYESHNR |
| MQSWIpYDDAWV | XIFGApYSRRRV |
| ASFSPpYNXXEL | VTLRApYNRRNI |
| AQWTXpYEFWEP | KSWRFpYRTKPQ |
| KVDTDpYDTRDG | XKHRGpYKKRWH |
| MWETDpYFDKGF | RTNSGpYMTRKK |
| PTHDDpYLQHRR | RRAVGpYSNRRH |
| WFSSEpYSMNDR | KASAIpYRRFAX |
| NTGDHpYITTFK | PKRAMpYSMIRR |
| KDANTpYIHSGR | VRRRMpYKNTWM |
| FETHVpYGNDSK | IRFGNpYGARKR |
| KLDNApYIDGFG | AFSWPpYKSRRR |
| KKDSApYNHLNM | RMRGQpYRRKVH |
| ASWSNpYMKHRH | IKRRRpYGSNRK |
| NSFTSpYTRAGW | GQIASpYRIRWR |
| VFENMpYRRHKR | MRAPVpYRRART |
| APQTVpYRKDWD | RSFXVpYRVRXX |
| Library V (150 mM NaCl) | |
| Class I | NFISQpYSQWDT |
| QTEPMpYSDKWD | FFGEWpYGNDRS |
| GSLTVpYEPMWE | FMGFEpYTIPEQ |
| TQLGEpYGGWHN | FNAPMpYEEWVG |
| SGWAFpYGSPER | EQTFSpYQDMWF |
| PESDApYSDWFQ | LIILSpYGWNDN |
| WEMDVpYQAHAH | NMWFWpYATPNE |
| PDGTPpYQWNED | KVEDWpYGESFP |
| EFEAFpYGQFEH | MGQDGpYGWNFE |
| AWEAVpYGEPED | NDMXXpYEWKVD |
| VAWMNpYGNQLD | XVNMVpYSMDFN |
| FFDGEpYTWDHT | REENLpYTQHWE |
a
M, Nle; X, unidentified amino acid.