. Author manuscript; available in PMC: 2012 Mar 29.

Published in final edited form as: Biochemistry. 2011 Feb 18;50(12):2339–2356. doi: 10.1021/bi1014453

Table 6.

Reported PTP1B, SHP-1, and SHP-2 Substrates and Their Dephosphorylation Sites

Substrate	Reported or predicted SHP-1 or SHP-2 site(s)	Ref.
PTP1B
Caveolin-1^*	DSEGHLpY¹⁴TVPIR	57
Cortactin^*	TEPEPVpY⁴⁴⁶SMEAA, PPpSpSPIpY⁴²¹EDAAP	58, 59
CSF-1R^*	ICTIDVpY⁹⁴⁴MIMVK	60
EGFR	TAENAEpY¹¹⁹⁷LRVAP	59
IR^*	DIYETDpY¹¹⁶²pYRKGGK	4
JAK2^*	LPQDKEpY¹⁰⁰⁷pYKVKE	61
LPP	PSSGQIpY²⁴⁵GPGPR, GRYYEPpY³⁰¹pYAAGPS, SEGDTApY³¹⁸GQQVQ	59
PDGFR	KDESIDpY⁷⁵¹VPMLD	59
PLCγ1	GTAEPDpY⁷⁷¹GALYE	59
p120ctn	PSRQDVpY²⁵⁷GPQPQ, RFHPEPpY²⁸⁰GLEDD	59
p62Dok	GpSPPALpY²⁹⁵AEPLD	59
p120RasGAP	VDGKEIpY⁴⁵¹NTIRR	59
c-Src^*	TSTEPQpY⁵²⁷QPGEN	62, 63
SHIP2	TLSEVDpY¹¹³⁶APGPG	59
STAM2	SEPEPVpY²⁹¹IDEDK, VNEAPVpY³⁷¹SVYSK, APVYSVpY³⁷⁴SKLHP, TVSNPTpY⁴⁶¹MNQNS	64
STAT5a	AKAVDGpY⁶⁹⁴VKPQI	65
Tyk2^*	VPEGHEpY¹⁰⁵⁴pYRVRE	61
ZO-1	EQPAPApY¹¹⁶⁴EVHNR	59
SHP-2
ASK1^†	?	79
EGFR^*	VVDADEpY⁹⁹²LIPQQ	66
FAK^*	VSETDDpY³⁹⁷AEIID, YMEDSTpY⁵⁷⁶pY⁵⁷⁷KASKG	67
GAB1	EADGELpY²⁸⁵VFNTP, PTPGNTpY³¹⁷QIPRT, EELDENpY⁴⁴⁷VPMNP, HDSEENpY⁵⁸⁹VPMNP	72
HER2^*	LVDAEEpY¹⁰²³LVPQQ	68
MVP^†	?	80
PAG	MVEDCLpY¹⁸¹ETVKE, KAEFAEpY²²⁷ASVDR, EEPEPDpY³⁸⁷EAIQT	73
Paxillin	LSEETPpY³¹SYPTG, GEEEHVpY¹¹⁸SFPNK	73, 74
PDGFRβ^*	KDESVDpY⁷⁵¹VPMLD, DIESSNpY⁷⁷¹MAPYD	69
PZR	KSESVVpY²⁶³ADIRK	75
p190A^*	NEEENIpY¹¹⁰⁵SVPHD	70
p190B	HPDYEEpY³⁰⁶INLEG, MDPSDNpY¹⁰⁹¹AEPID, GYSDEIpY¹¹⁰⁹VVPDD	76
SIRPα	DTNDITpY⁴²⁸ADLNL, PNNHTEpY⁴⁵²ASIQT, SEDTLTpY⁴⁶⁹ADLDM	77, 78
Sprouty 1^*	IRGSNEpY⁵³TEGPS, INVNNNpY⁸⁹EHRHT	71
STAT1^†	?	81
STAT5a^†	?	82
SHP-1
Actin^†	?	94
BLNK	DDFDSDpY⁷²ENPDE, HSDSEMpY⁸⁴VMPAE, ENADDSpY⁹⁶EPPPV, lEDEADpY¹⁷⁸VVPVE, EDNDENpY¹⁸⁹IHPTE	85
p120^ctn	GQIVETpY¹¹²TEEDP, GYDDLDpY²⁹⁶GMMSD	86
CD22	MEDGISpY⁷⁶²TTLRF, CDDTVTpY⁷⁹⁶SALHK, EDEGIHpY⁸²²SELIQ, AQENVDpY⁸⁴²VILKH	87
CD72	DDGEITpY³⁹ENVQV	88
p62^Dok	MLENSLpY¹⁴⁶SPTWE, PKEDPIpY³⁶²DEPEG, NPATDDpY⁴⁰⁹AVPPP	89
Lck^*	LIEDNEpY³⁹⁴TAREG	83
PIR-B^†	?	90
SHP-1^*	KGQESEpY⁵³⁶GNITY	84
SIRPα	DTNDITpY⁴²⁸ADLNL, PNNHTEpY⁴⁵²ASIQT, SEDTLTpY⁴⁶⁹ADLDM	90
SLP76	SFEEDDpY¹¹³ESPND, GEDDGDpY¹²⁸ESPNE, VEDDADpY¹⁴⁵EPPPS	91
Syk	PMDTEVpY³⁴⁸ESPYA, EVYESPpY³⁵²ADPEE	92
Vav1	VGDEDIpY¹⁴²SGLSD, EEDEDLpY¹⁶⁰DCVEN, AEGDEIpY¹⁷⁴EDLMR, EDYSEpY⁸⁴⁴C	93

The listed pY motifs in these proteins have been established as PTP1B, SHP-1, or SHP-2 substrates.

^†

No known pY sites match the specificity of SHP-1 or SHP-2.