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. Author manuscript; available in PMC: 2011 Apr 12.
Published in final edited form as: Tetrahedron. 2009 Aug 22;65(34):3771–6803. doi: 10.1016/j.tet.2009.05.079

Table 3.7.

Trisubstituted β-lactone synthesis.

graphic file with name nihms-194367-t0033.jpg

Entry R1 R2 R3 ee (%) Yield (%)
1 Et Et Ph 91 92
2 Et Et 2-Napthyl 89 77
3 Et Et p-CF3-Ph 80 74
4 −(CH2)6− Ph 82 71
5a i-Pr Me Ph 91 48
a

dr 4.2:1; ee is for the cis diastereomer, yield of both diastereomers.