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. Author manuscript; available in PMC: 2011 Apr 12.
Published in final edited form as: Tetrahedron. 2009 Aug 22;65(34):3771–6803. doi: 10.1016/j.tet.2009.05.079

Table 3.3.

Nelson's β-lactone products.

graphic file with name nihms-194367-t0029.jpg

Entry R R1 ee (%) dr (%) Yield (%)
1 H Cy 94a - 85
2 H BnOCH2 84 - 70
3 Me Ph(CH2)2 >99 96 84
4 Me p-F-Ph >99 >96 85
5 Me o-Cl-Ph >99a 96 80
6 Me o-Tol >99 >96 76
a

Runs with catalyst 7d, yields opposite enantiomer.