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. Author manuscript; available in PMC: 2011 Dec 1.
Published in final edited form as: Mol Microbiol. 2010 Oct 8;78(5):1294–1303. doi: 10.1111/j.1365-2958.2010.07405.x

Fig 5.

Fig 5

The working model of the Hfx. volcanii N-glycosylation pathway. Select Asn residues of the Hfx. volcanii S-layer glycoprotein are modified by a pentasaccharide comprising a hexose, 2 hexuronic acids, a methyl ester of hexuronic acid and a terminal mannose residue. Based on the findings of the present study and earlier reports (16,17,23–25,33), a working model of the Hfx. volcanii N-glycosylation pathway is provided. AglJ, AglG, AglI, AglE and AglD are assigned roles in either modifying dolichol phosphates or adding sugars to dolichol phosphate-bound sugars. AglB serves as the oligosaccharyltransferase, while AglF, AglP and AglM serve various sugar processing roles. At present, the flippase(s) responsible for delivering the lipid-charged glycans across the plasma membrane remain to be defined and are indicated by question marks. dolP, dolichol phosphate; NDP, nucleoside diphosphate.