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. Author manuscript; available in PMC: 2012 Mar 1.
Published in final edited form as: Ann Hum Genet. 2011 Mar;75(2):222–235. doi: 10.1111/j.1469-1809.2010.00632.x

Table 2.

Positional candidate genes on chromosome 16p.

Name Gene Symbol Genetic Location (cM)* Physical Location (bp)* Role
Calcium Channel, Voltage-Dependent, T Type, Alpha-1H Subunit CACNA1H 4.05–4.29 1,143,242–1,211,772 Allows for temporal and spatial control of intracellular calcium and supports regulation of cellular activity
Selenoprotein X SEPX1 6.45–6.44 1,933,295–1,928,235 Methionine sulfoxide reductase; functions as an antioxidant
ATP-Binding Cassette, Subfamily A, Member 3 ABCA3 7.16–7.05 2,330,748–2,265,880 Involved in regulation of lipid transport and membrane trafficking
Interleukin 32 IL32 8.24–8.25 3,055,314–3,059,668 Functions as a cytokine that induces TNFα, IL1β, IL6 and chemokines; plays a role in inflammatory and autoimmune diseases
C-type Lectin Domain Family 16, Member A KIAA0350 27.84–28.38 10,945,943–11,183,539 Unknown function; recently implicated in the development of type 1 diabetes
Suppressor of Cytokine Signalling 1 SOCS1 28.53 11,257,540–11,255,775 Inhibits signal transduction of some cytokines; abnormal expression of SOCS1 is involved in the development of leukemia, rheumatoid arthritis, liver cirrhosis, and liver cancer; ability to diminish insulin action
*

Genetic and physical positions relative to NCBI Build 36.