Table 3.

Association analysis of fine-mapping SNPs and positional candidate gene SNPs with quantitative measures of subclinical CVD in European American T2DM-affected individuals.

		p-values
Region/Gene	SNP	CorCP	CarCP	AACP	VCP-PC	IMT
CACNA1H	rs3809635	0.969	0.010	0.024	0.069	0.163
	rs11640796	0.079	0.127	0.955	0.073	0.577
	rs4347630	0.491	0.337	0.101	0.207	0.136
	rs4984636	0.332	0.600	0.299	0.430	0.567
	rs2745167	0.505	0.916	0.982	0.779	0.172
	rs4984637	0.014	0.651	0.322	0.105	0.027
	rs1054645	0.096	0.674	0.767	0.387	0.061
	rs1004041	0.033	0.896	0.675	0.295	0.101
	rs12934797	0.292	0.671	0.795	0.583	0.517
Chr16p13.13–13.3	rs1962736	0.077	0.884	0.296	0.389	0.474
SEPX1	rs13331553	0.590	0.499	0.458	0.635	0.283
	rs9934331	0.373	0.869	0.432	0.610	0.461
	rs1003904	0.954	0.502	0.728	0.787	0.177
	rs2252523	0.381	0.597	0.357	0.633	0.814
ABCA3	rs150926	0.887	0.720	0.557	0.732	0.862
	rs323074	0.451	0.960	0.946	0.988	0.707
	rs323069	0.943	0.970	1.000	0.771	0.183
	rs323066	0.949	0.749	0.965	0.822	0.602
Chr16p13.13–13.3	rs17660212	0.643	0.766	0.670	0.644	0.008
IL32	rs10438593	0.104	0.485	0.117	0.128	0.354
	rs7188573	0.902	0.080	0.591	0.222	0.181
	rs1554999	0.358	0.077	0.165	0.065	0.444
	rs2239301	0.153	0.602	0.941	0.624	0.462
	rs1555001	0.380	0.933	0.498	0.770	0.447
Chr16p13.13–13.3	rs129963	0.224	0.026	0.152	0.026	0.282
	rs11647778	0.008	0.674	0.222	0.130	0.530
	rs1358489	0.148	0.018	0.142	0.241	0.209
	rs7186211	0.688	0.079	0.292	0.263	0.205
	rs748987	0.765	0.067	0.020	0.230	0.049
	rs4337300	0.251	0.038	0.118	0.050	0.745
	rs11077123	0.091	0.531	0.725	0.404	0.823
	rs3785214	0.109	0.506	0.065	0.178	0.927
	rs2313980	0.599	0.006	0.552	0.056	0.185
KIAA0350	rs8055876	0.999	0.185	0.195	0.763	0.547
	rs16957849	0.479	0.779	0.163	0.781	0.327
	rs17803698	0.051	0.862	0.034	0.173	0.542
	rs7197758	0.297	0.942	0.139	0.690	0.980
	rs9940155	0.448	0.011	0.206	0.083	0.616
	rs723586	0.973	0.076	0.218	0.480	0.830
	rs7186166	0.052	0.046	0.083	0.037	0.748
	rs11074945	0.192	0.231	0.099	0.098	0.154
	rs8062923	0.986	0.981	0.641	0.920	0.993
	rs725613	0.325	0.645	0.061	0.189	0.136
	rs9652582	0.926	0.685	0.122	0.472	0.223
	rs12932833	0.463	0.908	0.401	0.716	0.982
	rs9926078	0.313	0.129	0.267	0.226	0.520
	rs12935657	0.761	0.614	0.621	0.494	0.823
	rs2003400	0.490	0.635	0.445	0.513	0.997
	rs794426	0.950	0.076	0.470	0.353	0.762
	rs7204935	0.193	0.318	0.407	0.219	0.724
	rs27838	0.455	0.150	0.239	0.152	0.870
	rs767019	0.891	0.194	0.994	0.453	0.766
	rs11643123	0.891	0.747	0.254	0.811	0.855
	rs3960630	0.791	0.180	0.700	0.406	0.698
SOCS1	rs243327	0.146	0.057	0.087	0.096	0.116
	rs243325	0.537	0.540	0.163	0.630	0.267
Chr16p13.13–13.3	rs350232	0.560	0.455	0.080	0.895	0.651
	rs1858992	0.923	0.388	0.083	0.366	0.506

Results are shown for all positional candidate gene SNPs and only the fine-mapping SNPs with evidence of association with at least one phenotype. P-values determined from the genotypic two degree-of-freedom test. CorCP = coronary artery calcified plaque; CarCP = carotid artery calcified plaque; AACP = abdominal aortic calcified plaque; VCP-PC= vascular calcified plaque principal component; IMT = intima-media thickness