Table 4.

Untransformed mean trait values by genotype (from individuals with both genotype and phenotype information available), model-specific p-values for associated SNPs and Hardy-Weinberg Equilibrium (HWE) assessment.

(A) Mean carotid artery calcified plaque scores by genotype for associated SNPs in intergenic region of chromosome 16p.

SNP	Alleles (Major/Minor)	MAF	Mean ± Standard Deviation			p-values				HWE (χ²)
SNP	Alleles (Major/Minor)	MAF	Mean ± Standard Deviation			Overall	Additive	Dominant	Recessive	HWE (χ²)
rs1358489	T/C	0.475	TT (n=158) 363.80±866.55	TC (n=338) 333.16±678.47	CC (n=163) 419.80±647.09	0.018	0.012	0.227	0.005	0.55
rs7186211	C/T	0.470	CC (n=170) 246.36±497.25	CT (n=314) 390.95±741.06	TT (n=164) 361.43±714.75	0.079	0.024	0.073	0.063	0.86
rs748987	G/C	0.479	GG (n=146) 410.11±718.85	GC (n=348) 351.02±759.90	CC (n=164) 339.36±634.57	0.067	0.177	0.026	0.966	0.32
rs4337300	C/T	0.463	CC (n=133) 361.09±695.82	CT (n=319) 343.47±747.72	TT (n=181) 378.04±717.61	0.038	0.080	0.863	0.012	0.92

(B) Mean coronary artery calcified plaque scores by genotype for associated SNPs in CACNA1H.

SNP	Alleles (Major/Minor)	MAF	Mean ± Standard Deviation			p-values				HWE (χ²)
SNP	Alleles (Major/Minor)	MAF	Mean ± Standard Deviation			Overall	Additive	Dominant	Recessive	HWE (χ²)
rs11640796	A/G	0.132	AA (n=458) 1349.92±2606.97	AG (n=139) 1353.31±2383.74	GG (n=14) 1860.96±1984.80	0.079	0.543	0.924	0.030	0.90
rs4984637	C/T	0.199	CC (n=405) 1482.44±2987.10	CT (n=171) 1447.82±2106.08	TT (n=34) 490.68±516.77	0.014	0.842	0.198	0.036	0.029
rs1054645	A/G	0.403	AA (n=220) 1334.96±2771.22	AG (n=257) 1572.21±2773.88	GG (n=108) 1031.06±1498.13	0.096	0.781	0.178	0.250	0.005
rs1004041	G/T	0.467	GG (n=193) 1134.06±1944.07	GT (n=248) 1693.03±3238.41	TT (n=143) 1360.63±2624.12	0.033	0.924	0.187	0.107	0.022

Models are reported relative to the minor allele. MAF = minor allele frequency.