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Amplifying endogenous H2O2 levels increases SNr GABAergic neuron firing rate. (A) Spontaneous firing from a SNr GABAergic neuron under control conditions and (B) after inhibition of GSH peroxidase with mercaptosuccinate (MCS; 1 mM). (C) Amplifying endogenous H2O2 with MCS caused a significant increase in the firing rate of SNr GABAergic neurons. (D) The regularity of firing as measured by the coefficient of variation was unaffected by increasing endogenous H2O2. (***p < 0.001).
