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. 2011 Apr 4;5:14. doi: 10.3389/fnsys.2011.00014

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Copyright © 2011 Lee, Witkovsky and Rice.

This is an open-access article subject to a non-exclusive license between the authors and Frontiers Media SA, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and other Frontiers conditions are complied with.

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Depletion of endogenous H₂O₂ with catalase slows the firing rate of SNr GABAergic neurons and decreases the regularity of their spontaneous activity. (A) Spontaneous activity of a SNr GABAergic neuron under control conditions and (B) after depletion of endogenous H₂O₂ with catalase (500 U/mL). (C) Catalase (Cat) caused a decrease in the spontaneous firing rate of SNr GABAergic neurons. (D) In addition, spontaneous activity became more irregular in catalase, reflected in an increase in the coefficient of variation. (**p < 0.01; ***p < 0.001).