Figure 5.

Flufenamic acid (FFA) reverses H₂O₂-induced increases in firing rate. (A) Spontaneous activity of a SNr GABAergic neuron under control conditions, (B) following H₂O₂ (1.5 mM) application, and (C) with FFA (20 μM) applied in the continued presence of H₂O₂. (D) The H₂O₂-induced increase in firing rate was reversed by FFA and the resulting firing rate suppressed below control. (E) Activity of another SNr GABAergic neuron under control conditions, (F) following amplification of endogenous H₂O₂ with MCS (1 mM), and (G) in FFA (20 μM) in the continued presence of MCS. (H) Increases in firing rate induced by amplified endogenous H₂O₂ were similarly reversed and suppressed below control levels by FFA. (*p < 0.05; **p < 0.01; ***p < 0.001).