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FFA-sensitive channels are tonically activated by H2O2 in SNr GABAergic neurons. (A) Spontaneous firing of a SNr GABAergic neuron under control conditions, (B) following depletion of basal H2O2 with catalase (500 U/mL), and (C) in FFA (20 μM) in the continued presence of catalase. (D) Catalase (Cat) caused a significant decrease in firing rate which was unchanged when FFA was added in the continued presence of catalase. (NS not significant; *p < 0.05).
