Skip to main content
. 2011 Apr 4;5:14. doi: 10.3389/fnsys.2011.00014

Figure 7.

Figure 7

H2O2 can alter SNr GABAergic neuron activity via both TRP and KATP channels. (A) Spontaneous firing of a SNr GABAergic neuron under control conditions, (B) with TRP channels blocked by FFA (20 μM), and (C) with H2O2 (1.5 mM) in the continued presence of FFA. (D) Following blockade of TRP channels, exogenous H2O2 suppressed SNr neuron firing. In some cases [as in (C)] a marked hyperpolarization was seen that was sufficient to silence the neuron. (E) This suppression of firing was prevented by the KATP channel blocker glibenclamide (Glib; 3 μM). (F) Recording from another SNr GABAergic neuron under control conditions, (G) with FFA (20 μM), and (H) with MCS (1 mM) in the continued presence of FFA. (I) Amplifying endogenous H2O2 levels with MCS caused a suppression of firing rate when TRP channels were blocked with FFA. (J) The MCS-induced suppression of neuronal activity was also prevented by glibenclamide. (NS not significant; *p < 0.05; **p < 0.01).