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. 2011 Apr 4;5:14. doi: 10.3389/fnsys.2011.00014

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Copyright © 2011 Lee, Witkovsky and Rice.

This is an open-access article subject to a non-exclusive license between the authors and Frontiers Media SA, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and other Frontiers conditions are complied with.

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Exogenous H₂O₂ suppresses the firing of SNr GABAergic neurons in mouse slices. (A) Whole-cell current clamp recording from a mouse SNr GABAergic neuron recorded in vitro under control conditions. (B) The same neuron recorded in the presence of exogenous H₂O₂ (750 μM) exhibited decreased firing rate and eventual hyperpolarization leading to cessation of spontaneous firing. (C) H₂O₂ caused a significant decrease in firing rate in SNr GABAergic neurons from mouse. (**p < 0.01).