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. Author manuscript; available in PMC: 2011 Jul 1.
Published in final edited form as: Nat Methods. 2010 Dec 5;8(1):85–90. doi: 10.1038/nmeth.1540

Figure 4.

Figure 4

The binding of Lyme disease and control sera on the BBG microarray: (a) comparison of IgG binding of sera from Lyme disease patients and control sera (tested at 1:100 dilution). The average RFUs are normalized in each serum sample by setting the binding of fraction 33 in control and patient serum to 100. (b) Distribution of binding by patient and control sera over six selected GSL-AOAB fractions (#12, 17, 26, 33, 39, and 40). Blue squares = individual control sera values, Red circles = individual patient sera values. P values, calculated with Student’s t-test, are given for the comparison of control to patient for the selected 6 glycans. * = P < 0.05. (c) Proposed structural characterization of bound fraction #12 by MS and MS/MS.