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. Author manuscript; available in PMC: 2011 Apr 12.
Published in final edited form as: Integr Biol (Camb). 2010 Aug 17;2(9):424–434. doi: 10.1039/c0ib00040j

Fig. 3. Patterns of mechanical stress and branching morphogenesis are affected by matrix stiffness.

Fig. 3

Mechanical stress profiles of tubules surrounded by matrices of different stiffness: (A) Ematrix = 680 Pa, (B) Ematrix = 860 Pa and (C) combined stress profiles. Frequency maps of branching tubules embedded in collagen gel crosslinked with (D) 0 and (E) 50 mM D-ribose. (F) Branch frequency increases as the stiffness of the collagen gel increases (G). Rheological measurements of collagen gels crosslinked with D-ribose. *p<0.05; Scale bars, 50 µm.