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. Author manuscript; available in PMC: 2011 Apr 12.
Published in final edited form as: Integr Biol (Camb). 2010 Aug 17;2(9):424–434. doi: 10.1039/c0ib00040j

Fig. 5. FAK is activated at tips of tubules and required for branching morphogenesis.

Fig. 5

(A) FAK pY397 immunofluorescence and (B) frequency map in engineered tubules. FAK pY397 immunofluorescence in (C) control cells and (D) cells expressing FAK Dter. Frequency maps of FAK pY397 in (E) control tubules and (F) tubules expressing FAK Dter. Frequency map of branching from (G) control tubules and (H) tubules expressing FAK Dter. (I) Western blot analysis of FAK pY397 and total FAK in tubules treated with Y27632 or calyculin A. FAK pY397 immunofluorescence in (J) control tubules and (K) tubules constructed in collagen crosslinked using ribose. *p<0.05; Scale bars, 50 µm.