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. Author manuscript; available in PMC: 2011 Apr 12.
Published in final edited form as: Integr Biol (Camb). 2010 Aug 17;2(9):424–434. doi: 10.1039/c0ib00040j

Fig. 6. Patterns of mechanical stress and branching morphogenesis are affected by tissue geometry.

Fig. 6

(A–C) FEM stress profiles of tubules of various geometry. Frequency maps of (D–F) FAK pY397 immunofluorescence and (G–I) branching from tubules of the corresponding geometries. Arrows denote regions of high mechanical stress that branch, and asterisks denote regions of high mechanical stress that do not branch. (J–L) Predicted concentration profiles of TGFβ around tubules of various geometry. (M–O) Relative strength of the mechanical and biochemical inputs as a function of position within the tissue. Scale bars, 50 µm.