Table 4.

Results of the univariate analysis of the relationship between MR parameters and time to biochemical recurrence. The adjusted model accounted for the effect of clinical stage, biopsy Gleason score and PSA. HG, IG, LG = high grade, intermediate grade, low grade. A hazard ratio greater than 1.0 indicates an increased risk of biochemical recurrence with an increase in the variable of interest.

	Covariate only model			Adjusted model
	HR	95% CI	P value	HR	95% CI	P value
MRI risk score	2.33	(1.80 – 3.02)	<0.0001	1.68	(1.15 – 1.24)	0.007
Index lesion variables:
Mean CC/C ratio*	1.12	(1.02 – 1.23)	0.02	1.04	(0.93 – 1.16)	0.47
# voxels in lesion	1.10	(1.06 – 1.13)	<0.0001	1.07	(1.04 – 1.11)	<0.0001
Max CC/C ratio*	1.08	(1.03 – 1.12)	0.0003	1.04	(0.99 – 1.09)	0.06
# HG voxels	1.10	(1.06 – 1.15)	<0.0001	1.08	(1.03 – 1.13)	0.002
# IG voxels	1.18	(1.12 – 1.25)	<0.0001	1.13	(1.06 – 1.21)	0.003
# LG voxels	1.08	(0.83 – 1.40)	0.58	1.09	(0.82 – 1.46)	0.56
# HG + IG voxels	1.10	(1.06 – 1.13)	<0.0001	1.07	(1.03 – 1.11)	0.0002
% HG voxels	1.03	(1.02 – 1.13)	<0.0001	1.02	(1.00 – 1.03)	0.03
% IG voxels	1.00	(0.99 – 1.01)	0.57	1.0	(0.98 – 1.01)	0.51
% LG voxels	0.97	(0.95 – 0.99)	0.009	0.98	(0.95 – 1.00)	0.08
% HG+IG voxels	1.02	(1.00 – 1.03)	0.009	1.01	(0.99 – 1.02)	0.39

^*Mean and max CC/C values are based on the 117 patients in which an MRSI lesion was identified.