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. Author manuscript; available in PMC: 2011 Dec 29.
Published in final edited form as: J Am Chem Soc. 2010 Dec 3;132(51):18103–18114. doi: 10.1021/ja104924b

Figure 2.

Figure 2

Figure 2

A,B) Bright field inverted microscope images of multifunctional popcorn shape gold nanoparticle conjugated LNCaP prostate cancer cells, A) Before therapy, B) After therapy for 30 minutes and after stained with Trypan Blue. C) TEM image showing deformation of nano-popcorn structure after popcorn shape gold nanoparticle conjugated LNCaP cells were exposed to 100 mW, 785 nm NIR continuous-wave radiation for 10 minutes, D) TEM image showing structure deformation and irreparable damage of cancer cell surfaces after 20 minutes radiation, purple circles are showing bubble formation. E) TEM image demonstrating irreparable damage of cancer cell surfaces when multifunctional popcorn shape gold nanoparticle conjugated LNCaP cells were exposed to 100 mW, 785 nm NIR continuous-wave radiation for 30 minutes, purple circles are showing bubble formation. F) Absorption profile demonstrating nanoparticle structural change after nano-therapy process. G) Plot showing cell viability measured by MTT test after popcorn shape gold nanoparticle conjugated LNCaP cells, PC-3 and HaCaT cells were exposed to 785 nm NIR continuous-wave radiation at different power dose. H) Plot demonstrated a comparison on photothermal therapy response between well characterized gold nanorod and popcorn shape gold nanoparticle, when multifunctional nanoparticle conjugated LNCaP cells are exposed to 100 mW 785 nm NIR continuous-wave radiation for different times.