Table 1.
Characteristics of the 86 patients included in the gene expression study, and the whole population of the trial that included 162 patients (BC: β-carotene; RP: retinyl palmitate; 13cRA: 13-cis-retinoic acid; NA: not available)
| Variable | Whole population | Patients included | Patients not | P -value |
|---|---|---|---|---|
| All patients | 162 (100) | 86 (100) | 76 (100) | <0.0001 |
| No oral cancer | 123 (76) | 51 (59) | 72 (95) | |
| Oral cancer | 39 (24) | 35 (41) | 4 (5) | |
| Follow-up time of the censored observations | 0.48 | |||
| Median | 7.47 | 7.11 | 7.71 | |
| Range(years) | 0.19–15.31 | 0.92–15.31 | 0.19–12.73 | |
| Sex | 0.97 | |||
| Female | 77 (48) | 41 (48) | 36 (47) | |
| Male | 85 (52) | 45 (52) | 40 (53) | |
| Race | 0.6 | |||
| White | 145 (89) | 78 (91) | 67 (88) | |
| Other | 17 (11) | 8 (9) | 9 (12) | |
| Alcohol history | 0.49 | |||
| Current | 93 (57) | 49 (57) | 44 (58) | |
| Former | 19 (12) | 8 (9) | 11 (14) | |
| Never | 50 (31) | 29 (34) | 21 (28) | |
| Smoking history | 0.009 | |||
| Current | 56 (35) | 22 (25) | 34 (45) | |
| Former | 65 (40) | 35 (41) | 30 (39) | |
| Never | 41 (25) | 29 (34) | 12 (16) | |
| Age | 0.57 | |||
| Median | 56 | 57.5 | 55 | |
| Range | 23–90 | 23–90 | 27–81 | |
| Treatment arm | 0.43 | |||
| BC-RP | 45 (28) | 21 (24) | 24 (31) | |
| 13cRA | 81 (50) | 47 (55) | 34 (45) | |
| RP only | 36 (22) | 18 (21) | 18 (24) | |
| Histology at baseline Dysplasia | 0.19 | |||
| Dysplasia | 53 (33) | 32 (37) | 21 (28) | |
| Hyperplasia | 109 (67) | 54 (63) | 55 (72) | |
| DeltaNp63 | 0.43 | |||
| Low | 109 (73) | 57 (70) | 54 (76) | |
| High | 40 (27) | 24 (30) | 17 (24) | |
| Podoplanin | 0.0009 | |||
| Low | 94 (63) | 41 (51) | 53 (77) | |
| High | 56 (37) | 40 (49) | 16 (23) | |