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Specific tension is reduced in mice lacking desmin, K19, or both IF proteins. Maximal tetanic tension of TA muscles was measured in situ in WT mice and in mice lacking desmin, K19, or both IF proteins. Data are reported as specific tension (force normalized to cross-sectional area). The absence of desmin in the desmin-null and DKO muscles yields identical changes in specific force. *Significantly different from WT (P < 0.001); †significantly different from WT and K19−/−.
