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Mice lacking both desmin and K19 are more susceptible to injury. Injury was induced by 15 large-strain lengthening (“eccentric”) contractions through a 90° arc of motion. Maximal torque was measured before and after injury in WT mice and in mice lacking desmin, K19, or both IFs. The individual mutants had little effect on susceptibility to high-strain injury, whereas the DKO mice were more susceptible. *P < 0.005.
