Table 1.
Properties of skeletal muscle lacking intermediate filament proteins
| FVB | K19−/− | Desmin−/− | DKO | Desmin−/− (129) | |
|---|---|---|---|---|---|
| Minimal Feret's diameter, μm | 36.6 ± 9.4 | 32.6 ± 9.7* | 33.8 ± 11.7* | 34.9 ± 12.0 | 30.6 ± 14.6* |
| Muscle mass, mg | 31 ± 1.5 | 28.2 ± 2.7 | 27 ± 1.9* | 28 ± 3.1 | 27 ± 1.1* |
| Resting length, mm | 11.7 ± 1.0 | 10.8 ± 1.0 | 11.0 ± 1.0 | 11.2 ± 1.0 | 11.0 ± 0.6 |
| CNFs, % | 1.2 ± 0.2 | 2.4 ± 1.6 | 4.9 ± 1.6* | 4.8 ± 1.3* | 3.2 ± 1.8* |
| Plasma CK, U/l | 70 ± 22 | 234 ± 29* | 74 ± 24 | 239 ± 36* | 73 ± 26 |
Values are means ± SD. K19, keratin 19; DKO, double knockout; resting length, length of muscle at which maximal activation of contraction (P0) is achieved; CNF, centrally nucleated fiber; CK, creatine kinase. All strains are FVB except 129SVJ (129).
*
P < 0.05.