Fig. 7.

Brief electrical events are enhanced by LTCC activation. A: original traces showing solitary short depolarizations (probably spontaneous excitatory postsynaptic potentials) that where consecutively observed in one neuron under control conditions and in the presence of 3 μM BayK or 3 μM isradipine, as indicated. B: analysis of similar recordings from three different neurons. The bars depict the area under the initial 100 ms of the depolarizing event for the three conditions. Data obtained in the presence of the LTCC modulators were normalized to the corresponding control value and are depicted as means ± SE. C: original traces show the effect of BayK and isradipine application on brief depolarizing events elicited by 250-ms long current injections. D: area above −50 mV (indicated by the dashed line in C) is depicted normalized to the corresponding control value. Results are given as means ± SE (n = 5). *Statistically significant difference of P < 0.05.