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Epidermal growth factor (EGF) stimulation of NHE3 activity is NHERF1 dependent in Caco-2/bbe cells. NHE3 activities were measured in Caco-2/bbe cells with or without exposure to EGF (200 ng/ml) for 30 min. EGF stimulated NHE3 activity (30–40%) in control cells (Cont; lentivirus-empty vector cells) and NHERF2-KD cells (NF2-KD) but failed to stimulate NHE3 activity in NHERF1 lentivirus knockdown cells (NF1-KD). Results are means ± SE. P values are effects of EGF (paired t-tests; n = 3).
