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Binding site of the FVIIa-inhibitory peptide on FVIIa molecule. A) The ribbon representation of the FVIIa heavy chain molecule (blue) in complex with the FVIIa-inhibitory peptide (green) B) Surface charge distribution of the heavy chain and the inhibitory peptide. Note that the inhibitory peptide is negatively charged binding to a positively charged region on the FVIIa molecule keeping the HA binding site on FVIIa molecule free.
