Table 1:

Designed Chimeric Peptides and Result of Structural modeling

Hemextin A (peptide)	Terminal link	Chimera (HA p + Lazarus p)	Structure Analysis
1.
A- LVPFLSKTAPEG	COOH-terminal	LVPFLSKTAPEG + EEWEVLCWTWETCERGEGVEEELWEWR	No recognisable fold was obtained
B- LVPFLSKTAPEG	NH2-terminal	EEWEVLCWTWETCERGEGVEEELWEWR + LVPFLSKTAPEG	No recognisable fold was obtained
2.
A- TCPEGKNLCYKMTMLKMPKI	COOH-terminal	TCPEGKNLCYKMTMLKMPKI + EEWEVLCWTWETCERGEGVEEELWEWR	No recognisable fold was obtained
B- TCPEGKNLCYKMTMLKMPKI	NH2-terminal	EEWEVLCWTWETCERGEGVEEELWEWR + TCPEGKNLCYKMTMLKMPKI	No recognisable fold was obtained
3.
A- KIPIKRGCTDACPKS	COOH-terminal	KIPIKRGCTDACPKS + EEWEVLCWTWETCERGEGVEEELWEWR	No recognisable fold was obtained
B- KIPIKRGCTDACPKS	NH2-terminal	EEWEVLCWTWETCERGEGVEEELWEWR + KIPIKRGCTDACPKS	Distinct fold wasobserve wafter modeling
4.
A- TCPEGKNLCYKMTMLKMCKIPIK	COOH-terminal	TCPEGKNLCYKMTMLKMCKIPIK + EEWEVLCWTWETCERGEGVEEELWEWR	Distinct fold was observe wafter modeling
B- TCPEGKNLCYKMTMLKMCKIPIK	NH2-terminal	EEWEVLCWTWETCERGEGVEEELWEWR + TCPEGKNLCYKMTMLKMCKIPIK	Distinct fold was observe wafter modeling
5.
A- LVPFLSKTCCEGKNLCYKMTMLKMPKI	COOH-terminal	LVPFLSKTCCEGKNLCYKMTMLKMPKI + EEWEVLCWTWE TCERGEGVEEELWEWR	Distinct fold was observe wafter modeling
B- LVPFLSKTCCEGKNLCYKMTMLKMPKI	NH2-terminal	EEWEVLCWTWETCERGEGVEEELWEWR + LVPFLSKTCCEGKNLCYKMTMLKMPKI	Distinct fold was observe wafter modeling
6.
A- KMPKICIKRGCTDACPKS	COOH-terminal	KMPKICIKRGCTDACPKS + EEWEVLCWTWETCERGEGVEEELWEWR	No recognisable fold was obtained
B- KMPKICIKRGCTDACPKS	NH2-terminal	EEWEVLCWTWETCERGEGVEEELWEWR + KMPKICIKRGCTDACPKS	No recognisable fold was obtained

Notes: + denotes the nine alanine spacer; HA p denotes the peptide fragment derived from hemextin A; Lazarus p denotes the peptide designed at Genentech CA, USA by Dr Bob Lazarus and his colleagues.