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. Author manuscript; available in PMC: 2012 Apr 1.

Published in final edited form as: Alcohol Clin Exp Res. 2011 Jan 18;35(4):726–734. doi: 10.1111/j.1530-0277.2010.01390.x

Table 2.

Pharmacokinetic Parameters (Means ± standard error)

Dose		Placebo Pretreatment	Kudzu Pretreatment
Cmax (mg/dL)	0.35 g/kg	54.42 ± 6.8	50.67 ± 7.4
Cmax (mg/dL)	0.7 g/kg	119.45 ± 6.8^*	121.71 ± 6.8^*
Tmax (minutes)	0.35 g/kg	53.33 ± 7.1	59.0 ± 7.8
Tmax (minutes)	0.7 g/kg	66.67 ± 7.1	55.83 ± 7.1
Absorption Rate¹ (mg.dL/min)	0.35 g/kg	1.137 ± .34	0.932 ± .37
Absorption Rate¹ (mg.dL/min)	0.7 g/kg	1.839 ± .34^*	2.653 ± .34^*
AUC_0-180 (mg.hr/dL)	0.35 g/kg	82.6 ± 21.2	84.9 ± 23.2
AUC_0-180 (mg.hr/dL)	0.7 g/kg	198.3 ± 21.2^*	228.8 ± 21.2^*
AUC_0-inf (mg.hr/dL)	0.35 g/kg	130.2 ± 44.7	110.8± 48.9
AUC_0-inf (mg.hr/dL)	0.7 g/kg	598.9 ± 44.7^*	533.3 ± 44.7^*
Elimination Rate² (mg.dL/min)	0.35 g/kg	0.279 ± .03	0.297 ± .04
Elimination Rate² (mg.dL/min)	0.7 g/kg	0.315 ± .036	0.388 ± .03

¹

Absorption Rate was calculated by dividing Cmax/Tmax (after Jones et al., 2004).

²

Elimination Rate is the slope of the elimination curve.

^*

0.7 g/kg dose significantly higher than the 0.35 g/kg dose. There were no significant differences due to pretreatment.