Fig. 3.

Feeding behavior and physical activity. The duration (A and C) and frequency (B and D) of access to food hoppers during light and dark phases were measured in male mice. Compared with neil1^+/+ animals, neil1^−/− mice spent significantly more time feeding and frequenting the hoppers only during the dark phase. Despite this modest difference in feeding behavior, there was no difference in average food intake between neil1^+/+ and neil1^−/− mice (not shown). E: voluntary wheel running activity was assessed over 10 consecutive dark and light cycles in neil1^+/+ and neil1^−/− mice. Although neil1^−/− mice tended to have reduced voluntary wheel running relative to neil1^+/+ counterparts, these differences were not statistically significant. Data are expressed as means ± SE of 5–6 animals/group. *P < 0.05 vs. neil1^+/+.