Fig. 4.
Fasted weight loss and energy expenditure by indirect calorimetry. Body composition (A) and 24-h energy expenditures (B–D) were measured in 14-wk-old male mice. Although total body weights were similar (A), lean body mass measured by MRI was reduced, and fat mass was increased in neil1−/− mice. Total O2 consumption (V̇o2; B) and CO2 production (V̇co2; C) were significantly lower in neil1−/− mice across both day and night cycles. When normalized to lean body mass (D), there were no significant differences in V̇o2 between neil1+/+ and neil1−/− animals. Data are expressed as means ± SE of 6 animals/group. *P < 0.05 vs. neil1+/+.