Table 1.

Plasma fatty acid composition

	Phospholipid, μg/ml		Free Fatty Acid, μg/ml		Cholesterol Ester, μg/ml		Triglyceride, μg/ml
	neil1+/+	neil1−/−	neil1+/+	neil1−/−	neil1+/+	neil1−/−	neil1+/+	neil1−/−
C14:0	0.71 ± 0.06	0.72 ± 0.06	0.43 ± 0.12	0.41 ± 0.05	1.25 ± 0.17	1.03 ± 0.15	1.26 ± 0.20	3.08 ± 0.33*
C16:0	208.4 ± 13.1	252.2 ± 29.5	6.6 ± 1.01	10.7 ± 1.4	13.7 ± 2.8	15.5 ± 1.4	39.0 ± 6.0	84.2 ± 7.9*
C16:1 (n-7)	6.2 ± 0.6	5.1 ± 0.8	1.3 ± 0.4	2.7 ± 1.0	9.0 ± 1.9	12.3 ± 2.2	7.0 ± 1.4	16.9 ± 3.0*
C18:0	124.6 ± 5.8	172.3 ± 12.1*	2.3 ± 0.14	4.0 ± 0.35	1.00 ± 0.32	0.90 ± 0.17	3.5 ± 0.4	7.7 ± 0.8*
C18:1 (n-9)	53.2 ± 4.6	61.2 ± 6.8	5.25 ± 1.34	7.8 ± 0.8	17.3 ± 1.7	28.5 ± 5.1	55.2 ± 8.6	123.5 ± 8.9*
C18:1 (n-7)	12.8 ± 1.2	21.2 ± 3.4*	0.46 ± 0.10	1.2 ± 0.1*	1.5 ± 0.2	3.02 ± 0.53	4.4 ± 0.7	15.3 ± 1.8*
C18:2 (n-6)	205.1 ± 17.2	240.2 ± 26.7	5.9 ± 1.4	8.0 ± 1.1	153.2 ± 27.0	203.6 ± 23.3	59.7 ± 12.7	103.9 ± 9.9*
C20:4 (n-6)	86.0 ± 3.4	96.7 ± 4.5	0.65 ± 0.13	1.27 ± 0.1*	83.3 ± 8.8	124.3 ± 7.1*	4.2 ± 0.7	6.3 ± 0.7
C20:5 (n-3)	7.7 ± 0.6	11.9 ± 1.6*	0.29 ± 0.04	0.62 ± 0.1*	11.0 ± 1.6	20.2 ± 2.8*	9.7 ± 1.9	7.3 ± 1.1
C22:6 (n-3)	53.8 ± 4.2	81.5 ± 9.5*	0.9 ± 0.18	2.0 ± 0.2*	16.0 ± 2.8	29.9 ± 3.7*	9.60 ± 1.8	24.8 ± 3.1*
Total	818.4 ± 46.8	1,020.0 ± 92.9	26.5 ± 5.2	40.8 ± 4.6	332.5 ± 41.9	455.0 ± 37.2	205.2 ± 35.7	424.5 ± 31.4*

Data are expressed as means ± SE for 4–5 neil1^+/+ and 5–6 neil1^−/− animals. Neil1, nei-like 1. Plasma fatty acids were extracted and separated by thin-layer chromatography prior to gas chromatographic analyses. Neil1^−/− mice had a generalized increase in almost all major fatty acids in circulating triglycerides relative to neil1^+/+ animals. Levels of major plasma fatty acid species as well as total fatty acids in each fraction are shown.

^*P < 0.05 vs. neil1^+/+.