Figure 3.
Targeting the cell with gold NPs (a) and optical generation and detection of the intracellular PNBs: the 1st one non-invasively amplifies optical scattering (b), while increasing the fluence of the pump laser pulse induces the 2nd PNB that mechanically damages the cell (c); I—stages of the PNB theranostic action, II—optical pulsed scattering images of one cell with the membrane border shown with a white line, III—optical time response of the PNB shows its lifetime, IV—bright field and V—fluorescent (ethidium bromide-specific) images of the cell show it before (a) and after the generation of the 1st (b) and the 2nd (c) PNBs.