effective population size | Number of individuals in a population who produce viable offspring. |
biased gene conversion | Recombination event in which one variant of genomic sequence is preferentially “copied/pasted” onto another one. |
fourfold degenerate sites | Positions within the coding sequence of a gene at which all four nucleotides encode the same amino acid. |
codon adaptation index | Measure of similarity between the codon usage of a gene and the average codon usage of highly expressed genes in a species. |
iso-accepting tRNAs | Subset of tRNAs that carry the same amino acid. |
horizontal gene transfer | Transfer of genetic material from one species into another. |
isochore | Large fragment of a chromosome characterized by homogeneous GC content. |
negative selection | A form of natural selection that suppresses alternative genetic variants in favor of the wildtype. |
ribosomal pausing | A temporary arrest of the ribosome during translation elongation. |
shotgun proteomics | Methods of quantifying protein levels in a complex sample, typically using mass spectrometry. |
RNAseq | Quantitative analysis of RNA in a complex sample by high-throughput sequencing. |
upstream open reading frames | Open reading frames located 5′ from the primary open reading frame; considered to inhibit translation of the primary ORF. |
ribosomal footprints | Fragments of mRNA that were protected by ribosomes from nuclease digestion in a ribosomal profiling experiment. |