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. Author manuscript; available in PMC: 2011 Apr 12.
Published in final edited form as: Nat Rev Genet. 2010 Nov 23;12(1):32–42. doi: 10.1038/nrg2899
effective population size Number of individuals in a population who
produce viable offspring.
biased gene conversion Recombination event in which one variant
of genomic sequence is preferentially
“copied/pasted” onto another one.
fourfold degenerate sites Positions within the coding sequence of
a gene at which all four nucleotides
encode the same amino acid.
codon adaptation index Measure of similarity between the codon
usage of a gene and the average codon
usage of highly expressed genes in a
species.
iso-accepting tRNAs Subset of tRNAs that carry the same amino
acid.
horizontal gene transfer Transfer of genetic material from one
species into another.
isochore Large fragment of a chromosome
characterized by homogeneous GC
content.
negative selection A form of natural selection that
suppresses alternative genetic variants
in favor of the wildtype.
ribosomal pausing A temporary arrest of the ribosome
during translation elongation.
shotgun proteomics Methods of quantifying protein levels in
a complex sample, typically using mass
spectrometry.
RNAseq Quantitative analysis of RNA in a
complex sample by high-throughput
sequencing.
upstream open reading frames Open reading frames located 5′ from the
primary open reading frame; considered
to inhibit translation of the primary ORF.
ribosomal footprints Fragments of mRNA that were protected
by ribosomes from nuclease digestion in
a ribosomal profiling experiment.