Table 1.
Kinetics of a rare variant A572D with or without the common polymorphism H558R
| Samples (variant Q1077 del) |
Peak INa | Activation | Inactivation | Recovery | INaL | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| pA/pF | n | V1/2 (mV) | n | V1/2 (mV) | n | τf (ms) | τs (ms) | As (%) | n | % | n | |
| SCN5A-A572/H558 (WT) | −309 ± 54 | 5 | −42 ± 2 | 4 | −72 ± 1 | 5 | 0.9 ± 0.1 | 23 ± 4 | 25± 3 | 5 | 0.4 ± 0.03 | 4 |
| SCN5A-D572/H558 | −296 ± 52 | 13 | −42 ± 2 | 8 | −75 ± 1 | 10 | 1.7 ± 0.3 | 30 ± 7 | 24 ± 3 | 10 | 0.4 ± 0.02 | 7 |
| SCN5A-A572/R558 (WT) | −347 ± 51 | 10 | −43 ± 2 | 7 | −70 ± 1† | 10 | 1.1 ± 0.1 | 22 ± 25 | 21 ± 5 | 9 | 0.3 ± 0.1 | 8 |
| SCN5A-D572/R558 | −207 ± 55 | 9 | −39 ± 2 | 8 | −76 ± 2* | 8 | 1.7 ± 0.2* | 52 ± 14* | 20 ± 1 | 8 | 0.9 ± 0.3* | 7 |
τf, τs = fast and slow time constants, respectively; As = slow component; WT = wild type.
*
P < .05 vs – SCN5A-A572/R558.
†
P < .05 vs – SCN5A-D572/H558 or D572/R558.