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CaSR antagonism with Calhex 231 blocks amino acid-induced CCK secretion. Cells were incubated in the presence or absence of Calhex 231 (20 μM) administered 5 min before addition of 20 mM l-phenylalanine, l-tryptophan, or 50 mM KCl. CCK released in the media was measured 15 min following the addition of test substances. *P < 0.05 and ***P < 0.005, amino acid vs. control; ▴P < 0.05 and ▴▴P < 0.01, amino acid vs. amino acid + Calhex 231. Results are from 1 of 3 experiments.
