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. Author manuscript; available in PMC: 2011 Apr 12.
Published in final edited form as: Nature. 2010 Jun 16;466(7304):383–387. doi: 10.1038/nature09195

Fig. 2. RBR-2 is an H3K4me3 demethylase that counteracts the effect of the ASH-2 methyltransferase complex.

Fig. 2

a, Western blot of rbr-2(tm1231) mutant worms (representative of 3 independent experiments). b, rbr-2(tm1231) mutant worms have a decreased lifespan. c, Western blots of rbr-2(tm1231) mutant worms treated with ash-2 RNAi (representative of 2 independent experiments). d, ash-2 knock-down does not extend the lifespan of rbr-2(tm1231) mutant worms. ash-2 mRNA was efficiently knocked-down by RNAi in rbr- 2(tm1231) mutant worms (Supplementary Fig. 3a). E.V.: empty vector. Statistics are presented in Supplementary Table 3.