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Mutation of S498A prevents ERK-dependent increases in Nox5 activity. COS-7 cells were cotransfected with either WT HA-Nox5 (A) or S498A (B) or T494A (C) mutants together with WT-ERK2 or control DNA (lacZ), and superoxide was measured in response to PMA (100 nM). Results are presented as means ± SE; n = 4 to 5 experiments. *P < 0.05 vs. lacZ control.
