Table 1.

Basic characteristics for the eight groups

Leptin Levels at day 28	BW/TL, g/mm	HW/TL, mg/mm	HW/BW, mg/g	Leptin, ng/ml
C57BL6/J
RA	1.60 ± 0.03	7.18 ± 0.16	4.50 ± 0.08	4.3 ± 1.1
RA + Leptin	1.59 ± 0.02	7.25 ± 0.11	4.52 ± 0.08	6.5 ± 0.9
IH	1.41 ± 0.04*	6.87 ± 0.23	4.88 ± 0.07*	1.6 ± 0.2
IH + Leptin	1.46 ± 0.05*	7.01 ± 0.17	4.88 ± 0.06*	8.1 ± 0.9†‡
ob/ob
RA	3.38 ± 0.05§	8.01 ± 0.17§	2.38 ± 0.04§	ND§
RA + Leptin	1.97 ± 0.07†§	7.45 ± 0.28	3.80 ± 0.25†§	6.7 ± 0.8†
IH	3.22 ± 0.10§	7.58 ± 0.20§	2.37 ± 0.08§	ND§
IH + Leptin	1.82 ± 0.09†§	7.37 ± 0.18	4.12 ± 0.16†§	7.0 ± 1.0†

Values are means ± SE, n = 4–12/group. See material and methods for calculations.

RA, room air; IH, intermittent hypoxia; BW, body weight; TL, tibia length; HW, heart weight.

^*P < 0.05 vs. RA,

^†P < 0.05 vs. no leptin,

^‡Significant interaction between IH and leptin;

^§P < 0.05 ob/ob vs. C57BL6/J wild-type (WT). ND = not detectable.