Table 2.
Biological pathway/function results from Ingenuity IPA 8.7 pathway analysis
| Biological Pathway/Function | P Value | No. of Proteins |
|---|---|---|
| Molecular and cellular functions | ||
| Lipid metabolism | 7.56E-04–4.86E-02 | 57 |
| Cellular assembly and organization | 1.63E-04–4.01E-02 | 51 |
| Molecular transport | 4.67E-04–4.01E-02 | 45 |
| Cell death | 4.12E-06–2.69E-02 | 15 |
| Drug metabolism | 1.80E-04–1.80E-04 | 6 |
| Physiological system development and function | ||
| Skeletal and muscular system development and function | 6.37E-07–4.87E-02 | 43 |
| Cardiovascular system development and function | 1.22E-03–4.94E-02 | 27 |
| Organ morphology | 1.22E-03–4.01E-02 | 21 |
| Tissue morphology | 6.37E-07–9.21E-03 | 18 |
| Diseases and disorders | ||
| Cardiovascular disease | 4.29E-04–4.01E-02 | 37 |
| Immunological disease | 1.24E-06–1.33E-04 | 15 |
| Inflammatory disease | 1.08E-04–1.08E-04 | 13 |
Pathway analysis was performed by searching the Ingenuity Knowledge Base (genes only, species = mouse) for direct and indirect relationships. All SNO site/peptide identifications from GSNO-treated samples (1% false discovery rate) were used for motif analysis.