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The 3-State Model of Myofilament Activation
The 3 average positions of TM are depicted. In the Blocked State (red), TM resides at the outer actin domain, Ca2+ binding to cTnC results in an azimuthal shift to the weakly bound Closed State (yellow) in the actin inner domain and myosin binding drives the final shift to the force-producing Open state (green).
